Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Wt1  WT1 transcription factor   (Synonyms: D630046I19Rik, Wilms tumor 1 homolog, Wt-1)
Results	Reference
1	J:170930 Asahina K, Zhou B, Pu WT, Tsukamoto H, Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver. Hepatology. 2011 Mar;53(3):983-95
1	J:311885 Bandiera R, Vidal VP, Motamedi FJ, Clarkson M, Sahut-Barnola I, von Gise A, Pu WT, Hohenstein P, Martinez A, Schedl A, WT1 maintains adrenal-gonadal primordium identity and marks a population of AGP-like progenitors within the adrenal gland. Dev Cell. 2013 Oct 14;27(1):5-18
1	J:185582 Barak H, Huh SH, Chen S, Jeanpierre C, Martinovic J, Parisot M, Bole-Feysot C, Nitschke P, Salomon R, Antignac C, Ornitz DM, Kopan R, FGF9 and FGF20 Maintain the Stemness of Nephron Progenitors in Mice and Man. Dev Cell. 2012 Jun 12;22(6):1191-207
1	J:154102 Cain JE, Islam E, Haxho F, Chen L, Bridgewater D, Nieuwenhuis E, Hui CC, Rosenblum ND, GLI3 repressor controls nephron number via regulation of Wnt11 and Ret in ureteric tip cells. PLoS One. 2009;4(10):e7313
1	J:304944 Carmona R, Barrena S, Lopez Gambero AJ, Rojas A, Munoz-Chapuli R, Epicardial cell lineages and the origin of the coronary endothelium. FASEB J. 2020 Apr;34(4):5223-5239
1	J:253680 Chung E, Deacon P, Park JS, Notch is required for the formation of all nephron segments and primes nephron progenitors for differentiation. Development. 2017 Dec 15;144(24):4530-4539
1	J:287010 Deacon P, Concodora CW, Chung E, Park JS, beta-catenin regulates the formation of multiple nephron segments in the mouse kidney. Sci Rep. 2019 Nov 4;9(1):15915
1	J:119857 Desmots F, Russell HR, Lee Y, Boyd K, McKinnon PJ, The reaper-binding protein scythe modulates apoptosis and proliferation during mammalian development. Mol Cell Biol. 2005 Dec;25(23):10329-37
1	J:173576 Di Giovanni V, Alday A, Chi L, Mishina Y, Rosenblum ND, Alk3 controls nephron number and androgen production via lineage-specific effects in intermediate mesoderm. Development. 2011 Jul;138(13):2717-27
1	J:117767 Di Renzo F, Doneda L, Menegola E, Sardella M, De Vecchi G, Collini P, Spreafico F, Fossati-Bellani F, Giavini E, Radice P, Perotti D, The murine Pou6f2 gene is temporally and spatially regulated during kidney embryogenesis and its human homolog is overexpressed in a subset of Wilms tumors. J Pediatr Hematol Oncol. 2006 Dec;28(12):791-7
1	J:204973 Dixit R, Ai X, Fine A, Derivation of lung mesenchymal lineages from the fetal mesothelium requires hedgehog signaling for mesothelial cell entry. Development. 2013 Nov;140(21):4398-406
1*	J:147670 Done SC, Takemoto M, He L, Sun Y, Hultenby K, Betsholtz C, Tryggvason K, Nephrin is involved in podocyte maturation but not survival during glomerular development. Kidney Int. 2008 Mar;73(6):697-704
1	J:316553 Dong L, Pietsch S, Tan Z, Perner B, Sierig R, Kruspe D, Groth M, Witzgall R, Grone HJ, Platzer M, Englert C, Integration of Cistromic and Transcriptomic Analyses Identifies Nphs2, Mafb, and Magi2 as Wilms' Tumor 1 Target Genes in Podocyte Differentiation and Maintenance. J Am Soc Nephrol. 2015 Sep;26(9):2118-28
1	J:178343 Essafi A, Webb A, Berry RL, Slight J, Burn SF, Spraggon L, Velecela V, Martinez-Estrada OM, Wiltshire JH, Roberts SG, Brownstein D, Davies JA, Hastie ND, Hohenstein P, A wt1-controlled chromatin switching mechanism underpins tissue-specific wnt4 activation and repression. Dev Cell. 2011 Sep 13;21(3):559-74
1	J:306457 Fiorentino A, Christophorou A, Massa F, Garbay S, Chiral M, Ramsing M, Rasmussen M, Gubler MC, Bessieres B, Heidet L, Fischer E, Pontoglio M, Developmental Renal Glomerular Defects at the Origin of Glomerulocystic Disease. Cell Rep. 2020 Oct 27;33(4):108304
1	J:210076 Greulich F, Farin HF, Schuster-Gossler K, Kispert A, Tbx18 function in epicardial development. Cardiovasc Res. 2012 Dec 1;96(3):476-83
1	J:101176 Grieshammer U, Cebrian C, Ilagan R, Meyers E, Herzlinger D, Martin GR, FGF8 is required for cell survival at distinct stages of nephrogenesis and for regulation of gene expression in nascent nephrons. Development. 2005 Sep;132(17):3847-57
1	J:293086 Guo B, Lyu Q, Slivano OJ, Dirkx R, Christie CK, Czyzyk J, Hezel AF, Gharavi AG, Small EM, Miano JM, Serum Response Factor Is Essential for Maintenance of Podocyte Structure and Function. J Am Soc Nephrol. 2018 Feb;29(2):416-422
1	J:213127 Jakus Z, Gleghorn JP, Enis DR, Sen A, Chia S, Liu X, Rawnsley DR, Yang Y, Hess PR, Zou Z, Yang J, Guttentag SH, Nelson CM, Kahn ML, Lymphatic function is required prenatally for lung inflation at birth. J Exp Med. 2014 May 5;211(5):815-26
1	J:189883 Kim ST, Adair-Kirk TL, Senior RM, Miner JH, Functional consequences of cell type-restricted expression of laminin alpha5 in mouse placental labyrinth and kidney glomerular capillaries. PLoS One. 2012;7(7):e41348
1	J:178935 Kitagaki J, Ueda Y, Chi X, Sharma N, Elder CM, Truffer E, Costantini F, Lewandoski M, Perantoni AO, FGF8 is essential for formation of the ductal system in the male reproductive tract. Development. 2011 Dec;138(24):5369-78
1	J:268317 Kumar DL, DeFalco T, A perivascular niche for multipotent progenitors in the fetal testis. Nat Commun. 2018 Oct 30;9(1):4519
1*	J:170390 Lindstrom NO, Neves C, McIntosh R, Miedzybrodzka Z, Vargesson N, Martin Collinson J, Tissue specific characterisation of Lim-kinase 1 expression during mouse embryogenesis. Gene Expr Patterns. 2011 Mar-Apr;11(3-4):221-32
1	J:63195 Mah SP, Saueressig H, Goulding M, Kintner C, Dressler GR, Kidney development in cadherin-6 mutants: delayed mesenchyme-to-epithelial conversion and loss of nephrons. Dev Biol. 2000 Jul 1;223(1):38-53
1	J:118250 Mahoney ZX, Sammut B, Xavier RJ, Cunningham J, Go G, Brim KL, Stappenbeck TS, Miner JH, Swat W, Discs-large homolog 1 regulates smooth muscle orientation in the mouse ureter. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19872-7
1	J:266356 Marable SS, Chung E, Adam M, Potter SS, Park JS, Hnf4a deletion in the mouse kidney phenocopies Fanconi renotubular syndrome. JCI Insight. 2018 Jul 25;3(14)
1	J:269227 Mathieu M, Drelon C, Rodriguez S, Tabbal H, Septier A, Damon-Soubeyrand C, Dumontet T, Berthon A, Sahut-Barnola I, Djari C, Batisse-Lignier M, Pointud JC, Richard D, Kerdivel G, Calmejane MA, Boeva V, Tauveron I, Lefrancois-Martinez AM, Martinez A, Val P, Steroidogenic differentiation and PKA signaling are programmed by histone methyltransferase EZH2 in the adrenal cortex. Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):E12265-E12274
1	J:309403 Nakagawa N, Xin C, Roach AM, Naiman N, Shankland SJ, Ligresti G, Ren S, Szak S, Gomez IG, Duffield JS, Dicer1 activity in the stromal compartment regulates nephron differentiation and vascular patterning during mammalian kidney organogenesis. Kidney Int. 2015 Jun;87(6):1125-40
1	J:309384 Neirijnck Y, Reginensi A, Renkema KY, Massa F, Kozlov VM, Dhib H, Bongers EMHF, Feitz WF, van Eerde AM, Lefebvre V, Knoers NVAM, Tabatabaei M, Schulz H, McNeill H, Schaefer F, Wegner M, Sock E, Schedl A, Sox11 gene disruption causes congenital anomalies of the kidney and urinary tract (CAKUT). Kidney Int. 2018 May;93(5):1142-1153
1	J:188836 Norden J, Greulich F, Rudat C, Taketo MM, Kispert A, Wnt/beta-catenin signaling maintains the mesenchymal precursor pool for murine sinus horn formation. Circ Res. 2011 Sep 2;109(6):e42-50
1	J:264647 O'Brien LL, Guo Q, Bahrami-Samani E, Park JS, Hasso SM, Lee YJ, Fang A, Kim AD, Guo J, Hong TM, Peterson KA, Lozanoff S, Raviram R, Ren B, Fogelgren B, Smith AD, Valouev A, McMahon AP, Transcriptional regulatory control of mammalian nephron progenitors revealed by multi-factor cistromic analysis and genetic studies. PLoS Genet. 2018 Jan;14(1):e1007181
1	J:273075 Phua YL, Chu JY, Marrone AK, Bodnar AJ, Sims-Lucas S, Ho J, Renal stromal miRNAs are required for normal nephrogenesis and glomerular mesangial survival. Physiol Rep. 2015 Oct;3(10)
1	J:195266 Reginensi A, Scott RP, Gregorieff A, Bagherie-Lachidan M, Chung C, Lim DS, Pawson T, Wrana J, McNeill H, Yap- and Cdc42-Dependent Nephrogenesis and Morphogenesis during Mouse Kidney Development. PLoS Genet. 2013 Mar;9(3):e1003380
1	J:264120 Rowan CJ, Li W, Martirosyan H, Erwood S, Hu D, Kim YK, Sheybani-Deloui S, Mulder J, Blake J, Chen L, Rosenblum ND, Hedgehog-GLI signaling in Foxd1-positive stromal cells promotes murine nephrogenesis via TGFbeta signaling. Development. 2018 Jul 9;145(13):dev159947
1	J:287023 Schnerwitzki D, Perry S, Ivanova A, Caixeta FV, Cramer P, Gunther S, Weber K, Tafreshiha A, Becker L, Vargas Panesso IL, Klopstock T, Hrabe de Angelis M, Schmidt M, Kullander K, Englert C, Neuron-specific inactivation of Wt1 alters locomotion in mice and changes interneuron composition in the spinal cord. Life Sci Alliance. 2018 Aug;1(4):e201800106
1*	J:121918 Schwab KR, Patterson LT, Hartman HA, Song N, Lang RA, Lin X, Potter SS, Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development. BMC Biol. 2007;5:15
1*	J:106710 Takemoto M, He L, Norlin J, Patrakka J, Xiao Z, Petrova T, Bondjers C, Asp J, Wallgard E, Sun Y, Samuelsson T, Mostad P, Lundin S, Miura N, Sado Y, Alitalo K, Quaggin SE, Tryggvason K, Betsholtz C, Large-scale identification of genes implicated in kidney glomerulus development and function. EMBO J. 2006 Mar 8;25(5):1160-74
1*	J:284147 Velecela V, Torres-Cano A, Garcia-Melero A, Ramiro-Pareta M, Muller-Sanchez C, Segarra-Mondejar M, Chau YY, Campos-Bonilla B, Reina M, Soriano FX, Hastie ND, Martinez FO, Martinez-Estrada OM, Epicardial cell shape and maturation are regulated by Wt1 via transcriptional control of Bmp4. Development. 2019 Oct 17;146(20):dev178723
1*	J:97217 Wagner N, Wagner KD, Hammes A, Kirschner KM, Vidal VP, Schedl A, Scholz H, A splice variant of the Wilms' tumour suppressor Wt1 is required for normal development of the olfactory system. Development. 2005 Mar;132(6):1327-36
1	J:102417 Wagner N, Wagner KD, Theres H, Englert C, Schedl A, Scholz H, Coronary vessel development requires activation of the TrkB neurotrophin receptor by the Wilms' tumor transcription factor Wt1. Genes Dev. 2005 Nov 1;19(21):2631-42
1	J:255737 Wei K, Diaz-Trelles R, Liu Q, Diez-Cunado M, Scimia MC, Cai W, Sawada J, Komatsu M, Boyle JJ, Zhou B, Ruiz-Lozano P, Mercola M, Developmental origin of age-related coronary artery disease. Cardiovasc Res. 2015 Jul 15;107(2):287-94
1	J:300975 Weiss AC, Rivera-Reyes R, Englert C, Kispert A, Expansion of the renal capsular stroma, ureteric bud branching defects and cryptorchidism in mice with Wilms tumor 1 gene deletion in the stromal compartment of the developing kidney. J Pathol. 2020 Nov;252(3):290-303
1	J:250205 Wu RC, Zeng Y, Chen YF, Lanz RB, Wu MY, Temporal-Spatial Establishment of Initial Niche for the Primary Spermatogonial Stem Cell Formation Is Determined by an ARID4B Regulatory Network. Stem Cells. 2017 Jun;35(6):1554-1565
1	J:324178 Wu Y, Duan P, Wen Y, Zhang J, Wang X, Dong J, Zhao Q, Feng S, Lv C, Guo Y, Namekawa SH, Yuan S, UHRF1 establishes crosstalk between somatic and germ cells in male reproduction. Cell Death Dis. 2022 Apr 19;13(4):377
1	J:340740 Xu J, Zhou X, Zhang T, Zhang B, Xu PX, Smarca4 deficiency induces Pttg1 oncogene upregulation and hyperproliferation of tubular and interstitial cells during kidney development. Front Cell Dev Biol. 2023;11:1233317
1*	J:166958 Yates LL, Papakrivopoulou J, Long DA, Goggolidou P, Connolly JO, Woolf AS, Dean CH, The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation. Hum Mol Genet. 2010 Dec 1;19(23):4663-76
1	J:275548 Yosypiv IV, Sequeira-Lopez MLS, Song R, De Goes Martini A, Stromal prorenin receptor is critical for normal kidney development. Am J Physiol Regul Integr Comp Physiol. 2019 May 1;316(5):R640-R650